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One of the major open challenges in next generation sequencing (NGS) is the accurate identification of structural variants such as insertions and deletions (indels).
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A major open challenge in systems biology is to model metabolic and regulatory networks in a unified mathematical framework.
Extending this to children with disorders like ADHD or other learning disabilities is a major open scientific challenge.
Major results of available experimental outcomes, current issues and trends are also reported, summarising still open challenges.
Their formation remains a major open question.
Winning a major opens doors.
In [7], architectures to support cognitive radio (CR) networks in SG applications, major challenges, and open issues have been discussed.
After an extensive literature survey, the major challenges and open questions of real-time secondary usage of spectrum are addressed here.
Open fractures of the tibia accompanied by massive segmental bone loss and critical vascular injury are major treatment challenges.
The Obama administration confronts a major challenge in keeping open a dialogue with Russia, while developing and preserving a united front with Europe against Putin's aggression.
Russia has major economic challenges," he said.
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