She said the costs of land and health care are major obstacles for most would-be farmers.
Following her along the many intellectual crosswalks of the book will pose no major obstacles for the general reader.
Still, Mr. Johnson does not appear to face major obstacles for confirmation by the Democratic-controlled Senate.
Where 63% of women believe that there continue to be major obstacles for women to get ahead, only 41% of men feel similarly.
Economic diversity and the inflexibility of labour markets were seen as the major obstacles for EU member states to exploit to the full the benefits of monetary union.
Moreover, the conflict with the FARC insurgency and the emergence of illegal right-wing armed groups became major obstacles for Uribe.
So at this point it is not clear whether there will be a centre-left government, which would continue the negotiations, or a centre-right government, which would pose major obstacles for a continuation.
The UN Office for Co-ordination of Humanitarian Affairs says that despite recent gains, "the continuing instability in parts of Somalia and access restrictions for humanitarian workers remain major obstacles for aid delivery" (pdf).
Vaccine delivery and health worker shortages are major obstacles for some developing countries, although Gates said he didn't believe more money should be diverted from the cost of vaccines to meet costs for infrastructure.
However, cost and viscosity are two major obstacles for their widespread industrial applications.
Poor solubility creates major obstacles for formulations and successful chemotherapy with ethaselen.
