Sentence examples for major obstacle to the development of from inspiring English sources

The ERTMS system aims at remedying for the fragmentation of the European rail network, identified as a major obstacle to the development of international rail traffic [19].

A major obstacle to the development of commercially successful electric vehicles (EV) or hybrid electric vehicles (HEV) is the lack of a suitably sized battery.

Two pharmacological barriers, however, remain a major obstacle to the development of peptide therapeutics: susceptibility to proteolytic degradation in vivo and inability to traverse the cell membrane.

Efficient design of high-affinity peptide ligands via rational methods has been a major obstacle to the development of this potential drug class.

Absorption windows in the proximal gut can limit the bioavailability of orally administered compounds and can be a major obstacle to the development of controlled release formulations for important drugs.

A major obstacle to the development of ontologies in support of the Semantic Web is the poor capability of current ontology techniques to handle very large ontologies, in particular regarding scalability of reasoners.

Unfortunately, health constraints due to various pathogens including parasites stand as one of the major obstacles to the development of cavy industry in the country.

DOI: http://dx.doi.org/10.7554/eLife.00825.002 The molecular changes underlying human myeloid malignancies remain difficult to unravel, posing major obstacles to the development of effective countermeasures.

A major obstacle to the economic development of Bangladesh has been a general lack of mineral resources.

This is a major obstacle to the understanding of disease progression and the development of therapeutics.

Resistance to chemotherapy is a recurring issue for all cancer types, and the development of MDR is a major obstacle to the effective treatment of gastric cancer [ 33].