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One major obstacle has always been Madison Square Garden, the massive sports arena that is perched on top of the station and whose presence makes almost any rational redesign of the waiting rooms and tracks below virtually impossible.
And while he will now focus on Wednesday's second-round match against Chinese Taipei's Yen-Hsun Lu, a major obstacle has been cleared from Murray's path to the final.
These tasks will require some additional resources, but resources are not the major obstacle to better cybersecurity; the major obstacle has been and remains confusion over the role of government and a lack of will".
A major obstacle has been contradictory results from studies examining SPMs.
For both of these unmet medical needs, a major obstacle has been the lack of cellular bioassays for compound screening.
Such registries exist in most countries, but a major obstacle has been the difficulties in accessing this information arising from data protection and other administrative requirements.
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One person briefed on the talks said, however, that a major obstacle had long been removed: Time Warner is no longer demanding that the NFL Network be placed on a digital sports tier, which costs subscribers extra and which network owners like the N.F.L. view as a graveyard.
Major obstacles have been overcome during the intervening period, including raising the millions needed to fund the extension and clearing an area once used as a local tip.
Currently, major obstacles have to do with data protection.
Two major obstacles have stood in the way of studying the immunological function of the pleural space of rodents.
Two major obstacles have hampered the progress of ADEPT: the needs for specific, accessible antigens and for chemically stable and defined antibody enzyme constructs of suitable molecular size.
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