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A region inside the major noncoding portion of the mtDNA was predicted to form stable stem-and-loop secondary structures with minimum free energy prediction varying between −123.60 and −49.74 kcal/mol.
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The central part of the major noncoding region is therefore regarded as the control region that regulates replication and transcription of the mitochondrial genome [ 5].
Therefore, these data also provide access to the expressed noncoding portion of the genome.
Translational efficiency may also be influenced by modifications in the noncoding portion of the genes.
The major noncoding region was regarded as the CR as it contains CSBs [ 37].
We are, in resorting to this hypothesis, for simplicity assuming that noncoding DNA is not carrying adaptive information and that a genome can experience a reduction in the noncoding portion without significantly influencing function.
It is becoming largely accepted that the noncoding portion of the genome rather than its coding counterpart is likely to account for the greater complexity of higher eukaryotes.
A higher quantity of low repeat numbers in the coding versus genomic SSRs may reflect the higher selective pressure of the coding portion compared to the noncoding portion of the genome.
The major noncoding regions of U. fimbriatus and U. ebenaui are 1,344 bp and 1,456 bp, respectively.
Uroplatus fimbriatus appears to retain a translocated tRNAGlu gene adjacent to the 5' end of the major noncoding region.
The major noncoding region of this species contains rather long arrays of repetitive sequences that were not completely sequenced.
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