Sentence examples for major negative regulators from inspiring English sources

By directly antagonizing PI3K activity, PTEN is one of the major negative regulators of the PI3K pathway [ 28, 29].

One possible mechanism of activation of HSF1 by STCA is through binding and inhibiting HSP90 or HSP70, the major negative regulators of HSF1.

This observation agrees with the role of Myc as a major promoter of proliferation and p53 and PTEN as major negative regulators of proliferation.

We also analysed GLI1 isoforms after increasing the strength of HH signalling through kd of the major negative regulators PTCH1 or SUFUH, by RNAi (with shPTCH1 or shSUFUH).

The gibberellin-GID1 interaction triggers the degradation of DELLA proteins, the major negative regulators of gibberellin signalling, via the 26S proteasome pathway [ 12- 15].

The ERK activation was neither linked to changes in the expression of main components of the pathway (i.e. NRAS, BRAF, MEK1/2 and ERK1/2) nor its major negative regulators (i.e. SPROUTY2 and RKIP).

As the PI3K/AKT/mTOR pathway is an important signaling pathway in regulating the cellular functions, PTEN is a major negative regulator of PI3K signaling.

Autophagy is tightly regulated by several cellular signaling pathways, and the major negative regulator is the serine/threonine kinase mammalian target of rapamycin (mTOR); however, the class III PI3K/Beclin-1 positivelysitively regulates autophagy [ 12].

mTOR is activated by Akt, a downstream product of phosphatidylinositol 3-kinase (PI3K), whereas the major negative regulator of mTOR is 5′ AMP-activated protein kinase (AMPK), which regulates intracellular energy status by sensing the AMP/ATP ratio [ 13– 15].

An earlier transcriptomic study in seven OS biopsies (Patino-Garcia et al, 2009) showed up-regulation of EBF2, a known transcription factor for osteoprotegerin (OPG), a major negative regulator of osteoclastogenesis (Khosla, 2001).

One major negative regulator of the alternative pathway in human blood is complement factor H FHH FH