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Viral loads were significantly higher among patients with major mutations, compared with patients minor/no mutations, although no differences in the CD4 counts were found.
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The analysis of distribution of the major clinical features among SOS1 mutation-positive subjects documented a significantly higher prevalence of fetal macrosomia in subjects with class 1B mutations compared to individuals with class 1A mutations (Fisher's exact probability = 0.024).
Over millions of years, an essential piece of DNA will gather few mutations compared with less important ones.
In the current study, published online in Neuron on 9 December, they report that among a group of 87 patients with major depression, nine carried the mutation, compared with only three people in a control group of 219.
One in 40 Ashkenazi women carry a harmful genetic mutation, compared to less than one in 100 women generally.
"We finally know what the major pathways are and what all the major mutations look like".
Two major mutations (C282Y and H63D) were determined for each patient.
Out of the 50 individuals, 34% were considered to have major mutations to Indinavir, and 66% had minor or no mutations to Indinavir.
Bold: major mutations.
Major mutations can also occur.
Both point mutations and major mutations are possible.
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