Sentence examples for major mutations are from inspiring English sources

Both point mutations and major mutations are possible.

23, 25 If any of these major mutations are present, Atripla should not be prescribed.

Two major mutations are known in the HFE gene: C282Y and H63D mutations.

Three major mutations are associated with sheep susceptibility or resistance to classic scrapie and BSE: at codons 136 (A or V), 154 (R or H), and 171 (R, Q, or H) (7 ).

Inspection of the final structural model indicates that some major mutations are present in the helicase and non-functional regions of PK-NCVI/Pk3a which presents some new non-covalent intermolecular (IM) interactions alongside of conserved sequence).

Major mutations are single residue replacements that alone are capable of significantly decreasing the susceptibility to one or more drugs in a particular class, they generally occur either at positions forming the inhibitor binding site or at nearby positions affecting its geometry, and they frequently appear in clinical samples sequenced from patients experiencing virologic failure.

In Greek territory, two major mutations were described.

Major mutations were most frequent among the 786 patients of Anglo-Celt ethnicity and least in the 229 Southern Europeans.

Two major mutations were also found in KRAS, G12D (n = 1) and G13D (n = 3), well known in colorectal cancer to predict a resistance to EGFR antibodies 35.

When we performed the clustering analysis in another cohort of 152 naïve patients from Central Italy, diagnosed between 1997 2000, we found that major mutations occurred alone in 10 (71.4%) of 14 patients with HIV-1 drug-resistant virus, more than 2 major mutations were observed only in 1 patient, and no clusters have been identified in both PR ad RT [ 39].

At the same time, this mutation was actually quite predictable and is obviously required: when science and technology concern all aspects of life in society, the way we are educated and the way we work, commute, communicate, and even reproduce, a major mutation is bound to take place.