Sentence examples for major molecular target from inspiring English sources

On the day of birth, butyrylcholinesterase (BuChE), an OP bioscavenger used as a biomarker of OP exposures, and acetylcholinesterase (AChE), a major molecular target of OP compounds, were significantly inhibited in the blood of CPF-exposed offspring.

Several lines of evidence were obtained that support Kv1.3 as a major molecular target for clofazimine.

In this context, EGFR, a HER family receptor tyrosine kinase, has emerged as a major molecular target.

The current concept of neuromyelitis optica is based on the idea that this disease might be an astrocyte disease with astrocytic AQP4 as a major molecular target of the adaptive immune response.

The dopamine transporter (DAT), a member of the neurotransmitter:Na+ symporter (NSS) family, terminates dopaminergic neurotransmission and is a major molecular target for psychostimulants such as cocaine and amphetamine, and for the treatment of attention deficit disorder and depression.

The major molecular target inhibited by all N-BPs is farnesyl pyrophosphate synthase (FPPS), an enzyme in the mevalonate pathway [ 22].

Thus, up-regulation of ATF3 and down-regulation of cyclin D1 are major molecular targets for treatment of colorectal cancer.

The major molecular targets mediating the anesthetic effects of etomidate in the central nervous system are specific γ-aminobutyric acid type A receptor subtypes.

This was the ideal medium to assess simultaneously the expression of five major molecular targets in cancerology, as well as their relationship to prognosis.

We have previously established that many of the phenotypes resulting from DAE are similar between flies and mammals, and that at least one of the major molecular targets (IGF signaling) is conserved (McClure et al. 2011).

Generated autoantibodies against major etiopathogenic molecular targets as neuroimmune markers of dementia were measured by ELISA in patient sera.