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This review of cartilage microscopy is restricted to a brief description of the major molecular components in cartilage and bone and an in-depth discussion of methods for the preparation of these tissues for examination by transmission electron microscopy.
In the present study, we have shown that Orai1, an ion channel in the PM, and STIM1, as a signal transducer from the ER, represent the major molecular components of SOCE in PCa epithelial cells: the siRNA-mediated knockout of any of them strongly diminishes ISOC in LNCaP cells.
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IgE has long been regarded as a major molecular component of atopic diseases, including asthma [10].
IgE has long been regarded as a major molecular component of allergic diseases, including asthma[10].
Kir6.2 subunit is a major molecular component of "cardiac" KATP channels.
Some of these molecular abnormalities carry important diagnostic, prognostic and/or predictive information, giving support for a major molecular component in future tumor characterization.
Endotoxin LPS are the major molecular component of the outer membrane of Gram-negative bacteria and may excite the local inflammatory response [ 15].
Ultimately, IHC for alpha-synuclein (αS), which is its major molecular component [ 168], is the most sensitive and specific gold standard to detect various types of Lewy pathologies.
The cardiac K-ATP channels are composed of Kir6.2 subunits in combination with SUR2A [ 20], while Kir6.1 subunit is a major molecular component of vascular smooth muscle K-ATP channels [ 21].
Here, we show that the recently identified Orai1 protein represents the major molecular component of endogenous store-operated Ca2+ entry (SOCE) in human prostate cancer (PCa) cells, and constitutes the principal source of Ca2+ influx used by the cell to trigger apoptosis.
Despite the concept of Kir6.2 and SUR2A subunits as the major molecular component of "cardiac" KATP channels [ 10], evidences also support that Kir6.1 is expressed in the heart of mice, and Kir6.1 and Kir6.2 may assemble into functional channel complexes [ 19, 20].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com