Sentence examples for major modifier of from inspiring English sources

Using quantitative trait linkage analysis, we identified Id2, a homolog of Id3, to be the major modifier of Id3 in limiting Vγ1.1Vδ6.3 T cell expansion.

The SNCA gene has recently been identified as a major modifier of age of PD onset.

HP1, a major modifier of PEV in mice and Drosophila, provides further evidence of sex bias in chromatin.

It has recently been shown that the SNCA gene is a major modifier of age of PD onset [ 23].

Detailed evaluations have shown that age at menopause is a major modifier of breast cancer risk in the postmenopausal years [ 26, 27].

This may pose problems for long-term comparative analyses, as other registries such as the Eindhoven Cancer Registry have been collecting socioeconomic data since their inception [ 20] and shown socioeconomic status to be a major modifier of survival likelihood.

Although these results do not rule out a contribution from tumor cell extrinsic responses to the Hipp+Dxr-response in vivo, they do indicate that components of the intrinsic cell death pathway are major modifiers of the Hipp+Dxr synergy response in vivo and do so at least in part by affecting cell sensitivity to Hipp and Dxr.

CONCLUSION: Using a sensitized mouse model, we identified major modifier loci that affect the genetically complex disease of heart failure.

Far from being hunter-gatherers, Native Americans are presented here as major modifiers and managers of the landscape, including builders of cities such as Tenochitlan, the Aztec capital, which boasted running water and botanical gardens and a population much higher than any European metropolis of the period".

Our study identifies Oxr1 as a modifier of three major cellular pathological features of ALS associated with Fus and Tdp-43 mutations: mis-localization and aggregation of mutant proteins, splicing defects and mitochondrial abnormalities.

We also evaluated whether LAT was interacting with KCTD13, MVP, and MAPK3, major driver and modifiers of the proximal 16p11.2 600 kb BP4-BP5 syndrespectivelyctively.