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"major modifications" is a correct and usable phrase in written English.
It can be used to refer to significant changes or alterations to something. For example: "The team is currently making a few major modifications to the design of the new car."
Exact(59)
Both steps are major modifications of earlier Bush administration pronouncements.
The third remaining shuttle, Endeavour, is undergoing scheduled major modifications.
The added weight required major modifications to Ryan's standard M-2 airplane.
His vehicle is a stainless-steel DeLorean with some major modifications involving plutonium.
A terrorist would have to do major modifications to adapt the sprayer's nozzles to produce a finer mist of particles.
"We don't anticipate any major modifications to the airplane," Mr. McNerney said.
Morningstar made major modifications to its ranking system in mid-2002, changing the composition of the peer group against which each fund would be judged.
The provision, known as New Source Review, requires older power plants to install state-of-the-art pollution controls when they undertake major modifications.
The agency says the companies made major modifications to expand or extend the life of older coal-burning plants without installing the proper pollution controls.
This requires major modifications to the existing infrastructure.
Science examines the major modifications proposed for six central targets.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com