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Human cells are one of the major model systems in studying aging mechanisms.
Xenopus laevis and its diploid sister species X. tropicalis are among the major model systems for the fields of molecular, cell, and developmental biology.
The authors compiled a curated set of peroxisomal proteins from two major model systems in which global proteomic studies of the peroxisome have been done: yeast and rat.
Accordingly, a systematic mapping of PPI on the scale of the whole proteome the interactome has recently become available for major model systems from yeast (Ito et al., 2001; Yu et al., 2008) to human (Gandhi et al., 2006).
To assess the likelihood of exclusive CckA/CtrA and PleC/PleD interactions in Wolbachia, we examined the cognate specificity residues in these proteins through amino acid alignments with other Anaplasmataceae homologs informed with data from co-crystalized HK/RR pairs of major model systems (Casino et al. 2009; Capra et al. 2012a; Capra et al. 2010).
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ADP-ribosyl cyclase activity was first described in the sea urchin egg twenty years ago [2] but molecular information regarding these enzymes in this major model system has not been forth-coming.
Zebrafish are also a major model system for the study of vertebrate development.
and migratory flycatchers (Ficedula spp). in Europe has been a major model system for competitive species interactions.
The tunicate Ciona intestinalis (Enterogona, Ascidiacea), a major model system for evolutionary and developmental genetics of chordates, harbours two cryptic species.
Human fibroblasts such as the normal diploid fibroblasts cell line IMR90 are the major model system to study replicative senescence (Shay et al., 1991; Narita et al., 2003).
DOI: http://dx.doi.org/10.7554/eLife.06967.031 The collection of motifs described here will further advance C. elegans as a major model system for the study of gene regulation.
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