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The major model parameters were those determining seed movements and survival in soil and seedling emergence.
We evaluated changes in the cost-effectiveness of one-time, population-wide, routine HIV screening when we varied major model parameters, one at a time, over a range of plausible values (Figure 2).
Major model parameters and their default value or range are listed in Table 1.
Leading systematic errors are determined from additional scenarios in which major model parameters are varied independently within an envelope of plausibility.
In our review of the existing PI models at provincial and local levels, we examined the validity of data that was used in supporting major model parameters.
Furthermore, a probabilistic sensitivity analysis was conducted to explore the overall uncertainty by varying all major model parameters simultaneously using a random number generator and appropriate distributions.
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These results indicate that the variations made to every (single) major model parameter examined, except a linear teriparatide phase out period equal to the duration of therapy, will generate Cost / QALY estimates for teriparatide vs. bisphosphonate which are less than the €50,000 per QALY threshold.
Other covariates showed no major impact on model parameters and were not included.
The predictions of this SDR based LES closure in the ORACLES burner and Volvo Rig configurations exhibit good agreement with experimental results without requiring any major modification to the model parameters.
This presents a major computational challenge because model parameters learned from one sample may not generalize to other samples.
The other covariates (see previous page), with the exception of ethnicity, showed no major impact on the model parameters and were therefore not included in the final model.
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