Sentence examples for major mode of action from inspiring English sources

Recent review articles have displayed that the major mode of action for MSCs is the establishment of a regenerative microenvironment in response to tissue injury [29, 30].

The present results also come in accordance with the suggestion of Martin and Pennington (1988) who reported that all macrolytic lactones have receptor-mediated effect on glutamate-gated chloride (Glucl) ion channels which has been directly correlated to nematocidal activity and considered as their major mode of action.

Oxidative stress is another major mode of action of arsenic exposure.

This data further suggest a major mode of action of CRTC1-MAML2 in transcriptional activation is mediated by CREB.

However, these tumours were primary bile duct tumours (Tannapfel et al, 2003) suggesting that a major mode of action in the treatment of HCC is the potent antiangiogenic potential of sorafenib.

Translational inhibition, which seems to be the major mode of action in animals, is performed by a riboprotein complex called RNA-induced silencing complex (RISC) consisting of the miRNA and proteins of the argonaute family [ 9, 10].

The present study was designed to test the hypothesis that disruption of estrogen homeostasis was a major mode-of-action for the observed effects.

The biological responses observed in the present study support the hypothesis that perturbation of estrogen homeostasis is a major mode-of-action for TBBPA-mediated cell proliferation and tumorigenesis previously observed in the uterus of TBBPA-treated Wistar Han rats.

This suggested that a major mode-of-action of DHA on the eicosanoid pathway would be down regulation of the production of prostaglandin F2 series autocrine hormones with apparently less impact on other enzymes involved in the production of other eicosanoids, as implicated by the low response by the majority of genes in the pathways to dietary DHA level.

Phenazines can accept or donate electrons, and therefore one of their major modes of action is the generation of reactive oxygen species (ROS), inducing an oxidative stress response that can potentially lead to cell lysis1.

The major modes of action by As that have been reported are DNA damage, oxidative stress, chromosome aberrations, apoptosis, DNA methylation, signal transduction, DNA repair, and cell proliferation (Chen et al. 2005; Hughes 2002; Rossman 2003).