HSP60 is the major mitochondrial chaperone and is essential in maintenance of mitochondrial proteostasis.
Furthermore, it is unclear whether Trak1 also functions in other mitochondrial processes besides regulating mitochondrial motility.
As a major mitochondrial deacetylase, Sirt3 regulates the activity of enzymes to coordinate global shifts in cellular metabolism.
Pos5 was described as an ATP-NADH kinase, located in the mitochondrial matrix and reported to play an important role in several mitochondrial processes requiring NADPH.
Sirt3-deficient animals exhibit striking mitochondrial protein hyperacetylation, suggesting that SIRT3 is a major mitochondrial deacetylase [25].
We found six major mitochondrial clades in A. lugubris.
A major mitochondrial dysfunction is likely to cause cell death.
The major mitochondrial DNA mutations occur in the genes encoding mitochondrial OXPHOS complexes and lead to dysfunctional OXPHOS activity.
Eric Verdin showed that mitochondrial proteins from SIRT3 KO mice are hyperacetylated, suggesting that SIRT3 is the major mitochondrial protein deacetylase.
Mitochondrial respiration is one of the major cellular processes that produce ROS.
