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These studies suffer from major methodological deficiencies and were of sub-optimal quality, limiting their validity and reliability.
The studies included in this review suffer from major methodological deficiencies and are of sub-optimal quality, limiting their validity and reliability for policy-making in the country.
This popular 'step function' approach contradicts biological thinking and has major methodological deficiencies, not least the reduced statistical power (Royston et al, 2006).
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It is limited, however, by two major methodological factors and a lack of ecological research.
The major methodological problem is the lack of a "gold standard" for the diagnosis of LM.
Ideally, this study should be replicated without the above confounding variables and methodological deficiencies.
Most of the studies suffer from the methodological deficiencies discussed above.
Maintaining blinding is a major methodological challenge in studying TENS.
Indirect land use changes are recognised but not included due to current scientific and methodological deficiencies.
However, several major methodological limitations prevent clear conclusions.
Reasons for rejection of indirect comparisons by IQWiG can be classified in either formal or methodological deficiencies.
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CEO of Professional Science Editing for Scientists @ prosciediting.com