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Maintaining blinding is a major methodological challenge in studying TENS.
Study of diet disease associations over long time-spans is a major methodological challenge.
In particular, such commercial software was unable to perform complex temporal analysis of classroom pedagogy, which remains a major methodological challenge for educational research [19].
The above integration strategy presents a major methodological challenge in that standalone intelligent tutoring systems have traditionally been "application islands" that cannot easily interact with other ITS and learning platforms (Roschelle and Kaput 1996).
Single molecule observation in cells and tissue allows the analysis of physiological processes with molecular detail, but it still represents a major methodological challenge.
Our results shed light on a major methodological challenge in current bird coloniality research and suggest the need of improving the treatment of data in animal grouping research in general.
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Even though the use of detailed micro-data (i.e., highly disaggregated data with respect to time, product groups and households) is superior to other approaches (e.g., Akbay et al. 2007; Lazaridis 2003; Majumder et al. 2012; Thiele 2008), we face two major methodological challenges when analyzing this household expenditure survey data for sheep and goat meat.
We show that major methodological challenges in using routine data arise from the difficulty of understanding the gap between patient and their 'data shadow'.
No matter how good the system is, major methodological challenges need to be overcome to evaluate such systems in a rigorous and clinically relevant way.
In our opinion, many of the major methodological challenges in using routine data have at their root the difficulty of understanding the data generating process.
The measuring of patient satisfaction through surveys is a common approach in quality management, while literature suggests major methodological challenges [ 36, 37] and indicates the development phase of instruments assessing patient perception of quality [ 38- 40].
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