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This review analyzes the major methodological caveats related to the design and conduction of trials addressing new active drugs in patients with failed primary CNS lymphoma (PCNSL) and provides some recommendations for their therapeutic management.
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Possible methodological caveats could be the Beavis effect (Beavis 1998) where through interacting small sample sizes and low heritability values major QTL are quickly overestimated, leaving smaller QTL undetected.
It is true that this approach, too, comes with serious methodological caveats, such as verifiability, selection bias or observer bias.
Several additional methodological caveats are worth noting.
We also underline the methodological caveats of the study.
Maintaining blinding is a major methodological challenge in studying TENS.
(Fodor 1975, Chapter 5, and Terence Horgan 1993 raise related methodological caveats about reductionism resting ultimately on multiple realizability. Bickle 1998, Chapter 4, responds to these).
However, several major methodological limitations prevent clear conclusions.
In the course of developing his anthropology, Ricoeur made a major methodological shift.
Comments: The findings are unreliable in view of the major methodological flaws.
In Colorado, all of the recent public polls have one or more major methodological shortcomings.
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