However, emerging evidences have shown TNF- α was one of the major mediators of cancer-related inflammation and acted as a tumour-promoting factor.
In neuronal-differentiated cells, P2Y2, P2Y6, P2X2 and possibly P2X2/P2X6 heteromeric receptors were the major mediators of purinergic receptor-mediated [Ca2+]i elevations.
The effect of GBP is mediated through the inhibition, at the transcriptional level, of major mediators of pathophysiological pathways.
Cysteinyl-leukotrienes are major mediators of airway obstruction and display proinflammatory effects.
Neurexins have been proposed to function as major mediators of the coordinated pre- and postsynaptic apposition.
In the present study, N-isopropylacrylamide based PLs interacting with histones, major mediators of sepsis, were synthesized.
Norepinephrine or cyclic AMP (cAMP), the major mediators of thermogenic induction, significantly upregulated GPR120 transcript (Fig. 1e) and protein levels (Fig. 1f) in brown adipocytes.
The mechanisms of T cell regulation by cytosolic and nuclear Chop and the interaction of Chop with additional major mediators of CD8+ T cell function remain unknown.
Platelets are major mediators of the immune response, particularly in cerebral malaria.
The Rho-associated kinases, ROCK 1 and 2 (here referred to as ROCK), are major mediators of Rho activity [13].
