Sentence examples for major mediator for from inspiring English sources
Moreover, when we further examined the effect of Bmi-1 on the expression levels of MMP-2 and MMP-7 in A172 and LN229 glioma cells, our result showed that neither overexpressing nor silencing Bmi-1 had any an effect on the mRNA and protein levels of MMP-2 or MMP-7 (Additional file 2: Figure S1), implicating that MMP-9 might be a major mediator for Bmi-1 mediated invasiveness of glioma cells.
In the presence of poor cell survival and engraftment, the mechanisms promoting beneficial results reported following stem cell transplantation have been subject to an increasing number of studies that suggest cell-mediated paracrine effects are likely the major mediator for the improvement in cardiac function and the attenuation or slowing of the maladaptive processes [ 10].
These data show that TrkB is the major mediator for acute BDNF-induced effects on striatal gene expression.
These findings demonstrate that VDAC2 is a major mediator for efsevin's effect on ncx1h deficient hearts.
Collagen I is the major mediator for PSC-SN-induced haptokinesis of Panc1 and haptotaxis of UlaPaCa by activating FAK signalling via binding to integrin α2 β1.
TEs silencing relies mainly on RNAi pathway directed methylation, and siRNA is the major mediator for CpHpH DNA methylation [ 22, 43].
ABCA1 is one of the major mediators for cholesterol homeostasis.
Lipid peroxides, intracellular calcium ions, glutamate and free radicals are the major mediators for cell damage and death [10].
Norepinephrine and epinephrine, catecholamine hormones that are major mediators for chronic stress-induced cancers, are implicated in the progression of a number of cancer cells, including gastric adenocarcinoma.
These three factors have been reported to be major mediators for the regulation of cell proliferation, differentiation, and transformation (Huang et al. 1999a, 1999b).
Since reactive oxygen species (ROS) is the major mediators for radiation induced damage [ 7], a treatment combining radiation with an antioxidant might provide a strategy for preventing radiation injury to normal tissues [ 8].
