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To determine pregnancy course and major malformation rate after intracytoplasmic sperm injection (ICSI).
Results: Four (6.2%) of the 65 infants examined either had a major malformation or were considered dysmorphic.
In order to evaluate the contribution of auricular MEMs, we constructed a computerized program, especially designed for the recording of auricular MEMs in connection with nonauricular MEMs, personal data, family, pregnancy and birth history, presence of major malformation and postural defects.
4, 5 The baseline prevalence of major malformation is known to be 1.5 3%.
The major malformation rate in the letrozole group was 1.2% (6/514) and in the CC group was 3.0% (12/397).
The use of chemotherapy during the first trimester increases the risk of spontaneous abortion, foetal death and major malformation and is generally contraindicated in this period.
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The drug, valproate, sold generically and under the brand name Depakote, remains the second-most-popular antiseizure medication used for epilepsy, but earlier studies found that use during pregnancy also increased the risk of developmental delays and major malformations.
Primary outcome was the rate of major malformations.
The primary objective was to determine whether bupropion increases the risks for major malformations above baseline.
Major malformations involving the craniofacies and/or eyes were noted in all drug-treated groups.
Conclusions: Congenital microcephaly is infrequently accompanied by major malformations and occurs rarely as part of a recognizable syndrome.
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