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In recent years, more than 20,000 hits phenotypically active against P. falciparum, one of the major malaria causing agents, were disclosed from three independent HTS campaigns [1 3].
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The damage excision processes are characterized by the mechanism of excision employed nucleotide excision repair (NER), base excision repair (BER) and mismatch repair (MMR ., The various repair pathway components have been identified in the genome of the major malaria-causing parasite P. falciparum.
According to Global Burden of Disease estimates, HBV and HCV together caused 1.3 million deaths in 2010 [ 6];on par with other major infectious diseases including malaria (causing 660,000 deaths in 2010) [ 7], tuberculosis and HIV (causing 1.4 and 1.7 million deaths in 2011, respectively) [ 8, 9].
One of the major virulence factors of the malaria causing parasite is the Plasmodium falciparum encoded erythrocyte membrane protein 1 (PfEMP1).
Impairment of cardiovascular parameters as shown by tachycardia and hypotension [ 12– 14] represents a major step towards malaria caused death.
Malaria, caused by several Plasmodium species, is the major life-threatening parasitic infection worldwide.
The major malaria vector in both communities is Anopheles gambiae while Plasmodium falciparum causes more than 90% of all malaria infections [27].
The two major malaria vectors (A.
Doctors are concerned that if not addressed the strain of malaria could spread throughout India and reach Africa, which accounts for 90 per cent of the world's malaria cases, causing a major public health crisis.
Falciparum malaria is a major parasitic disease causing widespread morbidity and mortality globally.
Despite several decades of control efforts malaria remains a major infectious disease, causing at least 250 million infections and nearly 1 million deaths per year [1].
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CEO of Professional Science Editing for Scientists @ prosciediting.com