Sentence examples for major limits of from inspiring English sources

The major limits of a thermodynamic approach of this type are discussed.

On this point of view, considering that one of the major limits of a therapy based on neuroactive steroids could be modifications in their plasma levels and their consequent peripheral effects, pharmacological treatments aimed to increase their levels in the nervous system could provide an interesting therapeutic option.

One of the major limits of this study was the sample size.

One of the major limits of this method is that there is a mixed population of the two types of CBC around the cutoff point.

However, apart from the small sample size, one of the major limits of our study in this regard is represented by the shortness of treatments.

This inherent mixed agonist/antagonist nature of tamoxifen is probably responsible for the two major limits of its successful therapeutic promise, i.e. tumor resistance, de novo or acquired, seen in many patients, and its adverse effects in other tissues.

In this method only two mixtures have been considered and as a major limit of this method, only one source has been considered active at each time instant.

The major limit of the study obviously lies in its retrospective design, the results being highly dependent on the quality of records in the medical charts.

However, a major limit of those three CT-scan signs lied in their poor sensitivity (19, 32 and 62%, respectively), making their diagnostic contribution irrelevant in most patients.

Due to technical limits of SEM-EDS only particles with diameter more than 0.6 μm can be analyzed and this is the major limit of this work, because in this way we cannot study the finest particles which are of great interest in the study of particulate matter.

The major limit of this depletion kit is its reduced plasma loading capacity of only 8 µl.