This study, however, had one major limitation which must be noted.
Despite many advantages of graphene-based electrodes, there remains a major limitation, which is low value of specific capacitance.
First of all, recall bias was the major limitation, which could be expected in population-based retrospective studies.
The approach is denoted expanded PLS (E-PLS) and takes advantage of the simplicity of use of two-way models for batch processes and tackles its major limitation which is over-fitting.
The major limitation, which arised from the retrospective nature of the study, was that data of normal colorectal mucosa were not included in the statistical models.
A major limitation, which applies to almost all observational studies evaluating PCT, is that there is no accurate gold standard for the outcome definition of bacterial infection.
The lack of institutional attention and coordination, career and funding opportunities, is a major limitation, which contrasts with other European experiences where Development Cooperation agencies see their academic institutions as an important resource for their international mandate.
A major limitation, which also applies to most investigations on unwanted fertility, is the difficulty to accurately capture the very concept of unintended pregnancy, as a number of authors have reported a tendency of women to revise the status of a pregnancy after birth [ 28, 29].
* those with major physical limitations which (a) limited their ability to engage in physical activity a lot and (b) estimated to last for more than 4 weeks or unsure.
While the results of this study have clarified the role of IDs in major depression, there are limitations which need to be considered when interpreting the results and looking at clinical implications.
