39 Previous studies investigating whether inhaled glucocorticoids can reduce the occurrence of recurrent wheeze after respiratory syncytial virus infection have yielded conflicting data and had major limitations, including small sample size, low dosage of treatment, mean age older than 12 months at inclusion, and lack of accurate tools to measure long term airways morbidity.
Major limitations include small numbers and the fact that diagnoses of the suicide victims are based on data accrued by proxy interviews.
Photocatalytic reactors for the degradation of gaseous organic pollutants often suffer from major limitations such as small reaction area, sub-optimal irradiation conditions and thus limited reaction rate.
The major limitations are the small sample size, the use of self report to assess lifetime depression duration and the lack of longitudinal data.
With the two major limitations of the small sample size and the fact that the CBT therapist administered outcome questionnaires, any conclusions can only be tentative until findings are replicated in a larger study with better blinding.
The major limitations were the small sample size of patients with invasive candidiasis precluding us from providing additional meaningful statistics and that we lack data on empirical antifungal treatment over the study period.
The major limitations are the small sample and unequal groups (n = 15 non completers vs. 48 completers) which increased the likelihood of Type II statistical error, precluded separate analyses of participants with early and later attrition and examination of bidrectionality of relationships using more sophisticated analytic methods such as structural equation modelling.
Major limitations include the relatively small amount of tissue that can be collected and the risk that the best representative parts are missed.
One of the major limitations studying ASC in small animal models may be the quantity of AT starting volume to isolate and expand the desired cell yield, in particular when multiple harvests are required.
In the revised version, major changes include: 1) The major limitations of this study (small number of patients in the stage II group; no information on ethnicity, smoking history, medications and/or comorbidities) are now clearly stated in Patients and Methods.
