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A few field-deployable assays (strip or lateral-flow immunoassays) are available but suffer from major limitations including poor detection limit and inability to provide quantitative results.
Prevention relies on vaccination which has several major limitations including the lag time for vaccine preparation and the low vaccination coverage rate.
That study had a number of major limitations, including the control subjects having no radiographic evaluation, incomplete evaluation of OA subjects, and only 12 months of follow-up.
Heparin has a number of major limitations, including a narrow therapeutic window of adequate anticoagulation without running an increased risk of bleeding and a highly variable dose response relation that requires monitoring by laboratory testing.
This method does, however, have several major limitations, including giving inadequate weight to studies reporting large and highly significant effects and giving too much weight to underpowered studies reporting 'no effect'.
Conventional methods for time-location collections (e.g. self-reported paper diary and telephone interview) have several major limitations, including omission of short trips and inaccurate reporting of trip duration [ 27, 28].
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Major limitations include their high cost and brittleness, traits which have hindered the commercial adoption of this technology.
The major limitations include non-idealities of the ion sputtering process, the constraints on the lateral resolution available to identify subcellular features, and the difficulties inherent in the determination of absolute elemental concentrations.
Major limitations include accessibility of the epitope, size limitations, perturbation of the structure of the viral protein by the inserted epitope, and enforcement of a non-native structure on the epitope.
Major limitations include the following.
Major limitations include nonrandomization of villages in the baseline study and losses to follow-up.
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important limitations including
considerable limitations including
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