Sentence examples for major limitations as from inspiring English sources

We are also grateful for the attempt to standardise techniques in imaging included in RECIST; however, these new criteria and guidelines have major limitations as well as important implications for diagnostic radiological workload.

Yet the software has major limitations, as children can turn off the features once they turn 13 — which seems like precisely the time when you would want to be monitoring your child's phone.

Drug leaching during hydrogel preparation and rapid dissolution of alginate at higher pH are major limitations, as it results in very low entrapment efficiency and burst release of entrapped protein drug, once it enters the intestine.

Nonetheless, determination of serum PSA exhibit some major limitations, as elevated levels closely correlate with both hyperplasia and cancer.

Unfortunately, dietary restriction (DR) has major limitations as an approach to improve human health and longevity.

Furthermore, as noted above, the SNP-to-SNP comparison has major limitations as it does not account for differences in genetic architecture between the two ancestries.

Their solution has a major limitation as they assume the network to be fully connected with each link having equal bandwidth.

Compared to the Coin or upcoming Plastc, this seems like a major limitation as those devices store an unlimited number of cards, but I never found this to be an issue.

Eggs do have a major limitation as, if they are too large, the shell has to be so thick to avoid breaking under the weight of the contents that gas exchange can't occur effectively and the developing embryo will asphyxiate.

Also, restricting the pilot to 6 months duration is a major limitation as it typically takes longer for communities to reach maturity [ 3].

This was measured on synthetic antigen and could be a major limitation as the overall affinity for native antigen was significantly higher.