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When that treaty was negotiated, it had no provision for verification, a major limitation because most of the nations suspected of making biological weapons have signed the accord.
First, the lack of renal biopsy is a major limitation because the pathological findings for diagnosing renal etiology are unknown.
Finally, use of cross-sectional data is a major limitation because measurements obtained at a single point in time do not capture individual growth trends.
This is a major limitation because subunit interactions are likely to be important in determining the force response and conformational changes.
Fourth, the selectivity of the stimulation, which is based mostly on the placement of the fiber, is a major limitation because the nuclei that are targeted are very small and have complex shapes.
The present was undertaken to overcome this major limitation, because to understand evolutionary patterns and modes from data on contemporary populations it is imperative to ensure a wide geographical and ethnic coverage.
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For reference standards, the second major limitation is availability because only a very small subset of all needed reference standards are available, which limits their advantage.
One major limitation is that because the samples from female sexual workers (FSWs) in the China-Myanmar border region were unavailable in this study, we were unable to obtain HIV-1 subtype characterization in this cohort, and could not find the direct evidence for the transmission association between LDTDs and FSWs.
The limited time of follow-up of most RCTs is a major limitation of our review because the time frame for cancer development might exceed the follow-up time in many RCTs.
Microdialysis contains a major limitation when estimating data because only an approximation can be stated.
We evaluated it as a major limitation of our study because the diagnosis of hypovolemia was based mainly on basic hemodynamic data and clinical impressions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com