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Discover Ludwig"major limitation" is correct and usable in written English.
You can use it when referring to a significant or significant restriction or difficulty. For example, "One of the major limitations of this technology is its cost."
Exact(59)
Major limitation is the relatively limited studies included.
There is one major limitation to the DPP-FP30's mobility, however.
Booting up cells with new genomes is a major limitation in synthetic biology, Dr. Venter said.
Mobile devices have one major limitation: light batteries.
A major limitation was the heterogeneity of variance between studies.
The major limitation of this study is the small number.
This is a major limitation of this study.
Sample size was a major limitation to the study.
This degradation phenomenon is a major limitation of PHWE.
Furthermore threshold handling is the major limitation of this approach.
One major limitation is the required backhaul bitrate.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com