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Liver fibrosis has been recognized as a major lesion of the liver that leads to liver cirrhosis at the end stage.
The major lesion type of ionizing radiation is considered to be the induction of DSB in the DNA molecule.
L. major lesion amastigotes were extracted from macrophages using the same procedure as above.
Degradation of the layered structures toward the major lesion and no layer at the lesion location was also observed although OCT signal under the major lesion was weak due to low backscattering from the thick cancer lesion.
The major lesion type was cartilage derived at 69.1%, followed by bone cysts 11.3% and osteogenic tumours 8.7%.
Histopathology analysis of the imaged area confirmed that the major lesion corresponds to squamous cell carcinoma (SCC) (Fig. 6(c)).
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The major lesions induced by ROS include oxidized bases/sugar fragments, AP sites, and SSBs.
The 3 major lesions are villitis (when the inflammatory process affects the villous tree), chronic chorioamnionitis (which affects the chorioamniotic membranes), and chronic deciduitis (which involves the decidua basalis).
Nevertheless, when major lesions occur, it becomes necessary to use biomaterials, which are not only able to endure the cellular proliferation and migration, but also to substitute the original tissue or integrate itself to it.
Classical histological and electron microscopy analysis revealed major lesions, characterized by cellular disorganization in the follicles, increasing intercellular spaces and the absence of the basal lamina in diseased tissues (Figure 1F and 1H, and Figure 2B) compared to healthy tissues (Figure 1G and Figure 2A).
These observations indicate that the major lesions induced by 4NQO are not repaired by hOGG1.
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