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It is also a major leading cause of cancer death among men of all races.
Clarke made the comments while promoting her drama Me Before You, the 29-year-old's first major leading romantic role.
Nunn added, "We were looking at a major leading player after she'd been with the company a couple of years".
It is the first major leading film role for Huston, who is currently filming Pride and Prejudice and Zombies, a movie version of the parody-fiction hit.
Isaac, breaking through into his first major leading film role, is the heart and soul of Inside Llewyn Davis, which contains lengthy sequences of him performing entire songs.
The Times believed that Cameron's "one-nation Conservative" agenda "will be drowned out by Tories debating Europe" and that "Tory modernisers may wince at echoes of the travails of John Major, leading to the defeat of 1997".
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The Division of Nutritional Sciences offers three majors leading to a Bachelor of Science degree.
The majors' leading winners, Josh Beckett of Boston and Chien-Ming Wang of the Yankees, each with 18 victories, opposed each other yesterday at Fenway Park.
A Bonus for Bonds Barry Bonds, the majors' leading home run hitter this season, has often balked when asked to participate in the home run contest.
Joe Mauer, the majors' leading hitter this season, has struggled in his career against C. C. Sabathia, going 5 for 23 (.217) with nine strikeouts and two walks.
Toronto took advantage of three errors by Montreal, which entered with the fewest errors in the majors, leading to four unearned runs.
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