Sentence examples for major joint destruction from inspiring English sources

Calcium pyrophosphate deposition (CPPD) may cause severe arthropathy, major joint destruction and treatment options are limited.

Rheumatoid arthritis (RA) is a systemic inflammatory disease in which persistent active inflammation leads to major joint destruction.

This might have been due to a rheumatic disease lasting for more than 8 years, resulting in major joint destructions.

Fibroblast-like synoviocytes (FLSs) are major players in joint destruction in RA.

Resident synovial cells, RA synovial fibroblasts (RASF), are major effectors of joint destruction and active contributors to joint inflammation [ 1].

IL-6 is believed to be one of the major factors in joint destruction, being a pleiotropic pro-inflammatory cytokine that is markedly upregulated at times of tissue inflammation.

Although periarticular as well as systemic osteoporosis and subsequent joint destruction are major complications of RA, the precise mechanisms remain unclear.

Both MMP-1, capable of cleaving intact collagen [ 44], and MMP-3, responsible for the cleavage of other extracellular matrix components [ 45, 46] and the subsequent increase of accessibility of collagen fibrils to other collagenases like MMP-1 [ 35, 42, 47], are presumed to be of major importance in the initial joint destruction in the pathogenesis of RA.

Rheumatoid arthritis (RA) is the most common inflammatory arthritis and a major cause of disability due to joint destruction and permanent deformity [ 1].

IL-1β is one of the major cytokines in arthritis driving inflammation and joint destruction [ 2, 4, 7].

Activated synovial fibroblasts (SFBs), whether irreversibly altered [ 1] or reversibly stimulated by the inflammatory microenvironment [ 2], are major components of the pannus and contribute to joint destruction by secretion of pro-inflammatory cytokines and tissue-degrading enzymes [ 3].