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"This case raises major issues about the investigative work done," Mr. Delmar said of Christian's case.
One CNN vice president, Keith McCallister, told The Times's Bill Carter that "this is not a tabloid story" but one "that raises major issues about the foreign policies of two countries" and "involves serious legal issues".
"This is a story that raises major issues about the foreign policies of two countries, that involves serious legal issues and that is of passionate interest to our viewers both here and around the world".
Bertacchini and Segre [58] addressed two major issues about social quality in culture-led urban regeneration plans.
However, there are two major issues about correlations: (1) time-delayed regulation is not likely to be inferred by simple correlations; (2) the relationships based on correlations are not direct and would suffer from a large number of false positive predictions.
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There's now a major issue about reforming welfare, getting people back to work, not having something for nothing.
"There is a major issue about the disabled access to the cabs, the number of cabs that could handle a wheelchair, and that is low in this plan," Mr. Cuomo said.
"There wasn't a major issue about money," Mikel said.
Today, a major issue about water pollution is the residual dyes from different sources (e.g., textile industries, paper and pulp industries, dye and dye intermediates industries, pharmaceutical industries, tannery and craft bleaching industries, etc)., and a wide variety of persistent organic pollutants have been introduced into our natural water resources or wastewater treatment systems.
If the Democrats want to win in November, (i.e., suffer no more than 'normal' losses), they need to force Republicans to take a clear, unambiguous position, on a major issue, about which Tea Partiers and Independents have diametrically opposed positions.
A major issue about the origin of the genetic system is to understand how coding rules were generated before the appearance of a family of coded enzymes, the aminoacyl-tRNA synthetases.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com