Sentence examples for major issue is whether from inspiring English sources

A major issue is whether the spatial organization of a cell within this 3D tissue microenvironment could modulate cell responsiveness to regulate cell fate decisions such as survival, and if so how.

As in all such screens, a major issue is whether the mutations observed are selected for in the cancer or are merely accidental 'passenger' mutations.

For 1a and 1b, the major issue is whether the observed PVR phenotype in the lymph gland is due to autonomous RNAi effects or due to non-autonomous, secondary effects of RNAi in circulating/sessile, non-lymph gland hemocytes.

A major issue was whether the master had to allow the slave to marry and what rights the owner had over slave offspring.

At the time, a major issue was whether Mr. Davis should drop the state's defense of Proposition 187, the 1994 initiative that barred illegal immigrants from receiving health care or education benefits.

One major issue was whether the legislation would divert funds from the oil spill liability trust fund.

You may recall that in the debate over a new gun bill earlier this year, the major issue was whether to expand the FBI background check system to cover private sales.

The major issue was whether a new bridge should be built along the same alignment as the existing bridge, or instead curve westward to make a more direct connection with the interstate's Exit 116.

One of the first major issues was whether to save Chrysler.

The major issues are whether the developer will submit to tighter environmental scrutiny and allow wage indexing.

Another major issue is to understand whether asthma symptoms in obese patients are often so difficult to control mainly due to comorbid factors.