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The model is composed of 28 submodels of every major intracellular process in M. genitalium.
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Specifically, the comparison focused on major intracellular processes that influence the different metabolizing rates between these two species.
Macroautophagy (hereafter referred to as autophagy) is a major intracellular degradation process conserved in all eukaryotic cells.
Further comparison of these two models in terms of their estimated parameter values aim to study the major intracellular kinetic processes that contribute to the differences in metabolism between humans and rats.
The MAPK/ERK and PI3K/Akt pathways are the major intracellular signalling modules, which are known to regulate different cellular processes including cell proliferation, survival and malignant transformation [28], [29], and represent the upstream factors involved in AP-1 transcription factor activation [30], [31].
The lack of these bands within the concentrated ICF samples indicates that these samples did not contain major intracellular contaminations and that cell lysis played only a minor role during the vacuum infiltration process.
Autophagy is a major intracellular catabolic pathway induced in response to amino acid starvation.
By contrast, the sequestration of pDNA in intracellular vesicles and the low number of pDNA close to the nuclear envelop are identified as the major intracellular barriers.
Mitophagy is an essential intracellular process that eliminates dysfunctional mitochondria and maintains cellular homeostasis.
Autophagy is a major intracellular degradation system.
Trx is a major intracellular protein-disulfide reductase [6].
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