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In our study, docking of novel compound with 2ZJ4 showed binding interaction of Keto group of the novel compound established the hydrogen bond with SER 473 which is the major interaction of the ligand with 2ZJ4.
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Furthermore, the major interactions of the inhibitor 13f with HIV-1 RT were also investigated using the molecular modelling.
Consequently, we need to be alive to the possibility of many (potentially major) interactions of which we are as yet ignorant.
We have shown that Fog-1 G1Δnab-sensitised RBCs can adhere to macrophages without this resulting in phagocytosis and that the major interactions of G1Δnab Ab are with FcγRII.
The 25th oxygen atom of the molecule produced one ligand point interaction with Arg120 residue which allows major interaction impact of the tyrosine derivatives on catalytic domain of COX-2 protein.
Ferguson-Miller et al. have, indeed, identified residues Glu148, Glu157, Asp195, and Asp214 (all in subunit II of CcO from R. sphaeroides) as the major interaction partners of Cc [ 37].
Using YFPC-fused RH proteins and YFPN fusions of the TGA proteins determined to be the major interaction partners of NH proteins from the split YFP assay (rTGA2.1, rTGA2.2, rTGA2.3, rLG2, TGAL2, and TGAL4), we tested whether the introduction of various NH proteins (non-YFP fusions) was able to facilitate interaction between YFPN and YFPC fusions, yielding a fluorescence signal.
The lymphocyte tyrosine kinase Lck is the major interaction partner of Tip and phosphorylates Tip at specific tyrosine residues.
However, the additional genes identified in Step 2 enabled us to decode major interaction networks of grain yield and grain dry matter content (Table 1).
In summary, the split YFP and Y2H results indicate that NH1 and NH3 are the major interaction partners of rice TGA proteins (depicted as solid dark lines).
Although as a group novel agents have fewer drug-drug and food-drug interactions than warfarin, there are specific, major interactions to be aware of.
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