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Previously, many reports have shown that microglial cells may be a major inflammatory cell of the brain [ 14].
In turn, macrophages represent the major inflammatory cell type in alveolus, thereby strongly influencing total cell count values [ 29, 30].
A consistent finding in most fibrotic diseases of the lungs is the presence of T lymphocytes, one of the major inflammatory cell types.
Indeed, neutrophils are activated by these cytokines and these cells are one of the major inflammatory cell types recruited to the pulmonary compartment of COPD patients.
Here, we show that local rhTNF treatment is only effective when administered within 24 h of injury, when neutrophils are the major inflammatory cell infiltrate.
Neutrophils are the major inflammatory cell type infiltrating the injured mucosa following exposure to ethanol [ 26] and strategies to counteract the infiltration and/or activation of neutrophils have been shown to protect animals against gastric ulcers [ 27].
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Microglia being one of the major inflammatory cells of the CNS, we investigated the changes undergoing in them, on exposure to B[a]P, and the resulting changes in neuron-microglia interaction.
Macrophages are the major inflammatory cells accounting for this response.
Monocytes/macrophages are the major inflammatory cells constituting breast tumor microenvironment [ 32, 33] and contributing to high levels of growth factors, hormones, and cytokines [ 34, 35].
Th17 cells form the other major inflammatory T cell subset found in the intestines.
Microglia are key players of the immune response in the CNS and represent the resident immune host defense and are considered the major immune inflammatory cells of the CNS [12], [13].
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