Sentence examples for major induction of from inspiring English sources

Time course studies in macrophages over a period of 72 hrs showed a small and transient increase in ERα at 6 hrs E2 treatment; however, the major induction of ERα mRNA occurred at 72 hrs.

We have observed a major induction of PGC-1 α mRNA in adipose tissue of tumour-bearing mice.

Inhibition of proliferation did not appear to occur by straightforward inhibition of cell cycling or by a major induction of apoptosis.

> -wrap-foot> In addition to the autophagy pathway, the SILAC data provided evidence for a major induction of the ubiquitin proteasome system (UPS).

The major induction of accessory enzymes instead of xylan main chain hydrolases may be explained due to the small degree of polymerization (DP) of the model oligosaccharides tested, which could be A. oryzae hydrolytic products of main chain hydrolases.

While the 70 kd heat shock protein (Hsp70) overexpression inhibits SG formation, we did not observe major induction of Hsp70 after short-term co-treatments with MG132 or arsenite and NH4Cl (Supplementary Figure S3F), or with overnight treatment with leupeptin, E64d and pepstatin A (Supplementary Figure S3G).

The supernatant from clone FUSAOX showed two major induction bands of equal intensities and with apparent molecular masses similar to those of the individual enzymes produced by clones EGLAOX (~50 kDa) and CBHAOX (~60 kDa) (Fig. 4, lane 4), thus confirming that the protein fusion had been successfully processed with no detected unprocessed products (~120 kDa).

The process of autophagy involves two major steps: induction of autophagosome and fusion of autophagosome with lysosome (Fig. 1).

Indeed, upon microbial colonization of germ-free mice, major transcriptional induction of innate and adaptive immune genes occurs as early as 4 days after microbial inoculation, and includes activation of expression of antimicrobial peptides, lineage transcription factors of T cells, cytokines, and molecules involved in antigen presentation [ 37].

The prevailing general mechanism for vesicle budding in the secretory and endocytic pathways is the assembly on the donor membrane compartments of a 'coat', whose core and accessory subunits are responsible for two major functions: induction of bilayer deformation and protein cargo selection (Faini et al., 2013).

As the most potent cells activating and polarizing naive T cells, oral dendritic cells (DCs) are of major importance in induction of immunity and tolerance.