Accelerated red blood cell turnover is a major cause of imprecision of A1C.
Indeed the MDRD Study equations were developed in people with CKD, and as such their major limitations are imprecision and systematic underestimation of measured GFR at higher levels of kidney function [ 76].
Trypsin digestion, in particular, was shown to be a major factor of analytical imprecision [ 13].
This is an additional reason why the subjectivity in operator-dependent calliper placement is likely to be the major source of measurement imprecision and contributor to interoperator measurement variability, especially for the IRT but to a lesser extent the other time intervals.
A major challenge of this study was the imprecision of exposure assessment that we based on monthly municipal level air pollutant information.
A major challenge of this study was the imprecision of exposure assessment from using aggregate municipal measures for classifying individual exposures.
However, despite its widespread use, it is known that the major limitations of the MDRD study equation are imprecision and systematic underestimation of measured GFR (bias) at higher values (1, 6, 7).
Our observation of associations of lower cognitive scores with major roadway proximity but not with traffic density may stem from imprecision in our estimates of traffic density or uncaptured variability in the traffic pollution sources represented.
In Shahîd's judgment, the imprecision and unemphatic tone of Eusebius' passage at 6.34 is the major cause of the lack of scholarly consensus on Philip's Christianity.
On further examination, we discovered that the imprecision of the GIS data, such as the address codes and thus the distance to major roads, could be as large as 100 m, depending on the geocoding algorithm.
All major risk factors with multiple studies were downgraded because of study quality, as their median Newcastle-Ottawa scale score was always below 7. Inconsistency and imprecision were also common for most major risk factors (tables 3-5).
