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Pancreatic cancer is a devastating disease with the worst prognosis among all the major human malignancies.
Somatic hypermutations in tumor suppressor genes involved in major human malignancies offer a novel insight in cancer development, progression and spread.
Colon cancer is one of the major human malignancies.
This is the largest analysis of Ep-CAM expression in major human malignancies performed to date.
Cancers of the colorectum, breast and prostate constitute major human malignancies for which effective and safe chemoprevention strategies are scarce.
We profiled 250 primary cancer samples representative of major human malignancies, and detected a total of 100 mutations in 86 (34%) of the cases (Supporting Information Table S2).
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The latent membrane protein (LMP1) encoded by EBV is expressed in the majority of EBV-associated human malignancies and has been suggested to be one of the major oncogenic factors in EBV-mediated carcinogenesis.
Hepatocellular carcinoma (HCC) is among the most frequent human malignancies and a major cause of cancer-related death worldwide.
Hepatocellular carcinoma (HCC) is one of the most frequent human malignancies and a major cause of cancer-related deaths worldwide (Okuda et al, 1992).
However, mutational analysis attempted to find any genetic abnormalities of AKT kinase domains in common human malignancies revealed no major genomic alterations in the three AKT isoforms (Soung et al, 2006), although some reports described some minor alterations in some of the isoforms associated with specific malignancies (Robertson et al, 2005).
Anticancer drug resistance almost invariably emerges and poses major obstacles towards curative therapy of various human malignancies.
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