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Our findings demonstrate that it should be possible to develop 'pan-reactive' drug-like compounds that inhibit SUB1 in all three major human malaria pathogens, enabling production of broad-spectrum antimalarial drugs targeting SUB1.
For one, similar research efforts are needed to reduce transmission of Plasmodium vivax, another major human malaria parasite.
Unlike the other major human malaria parasite, P. falciparum, there is no in vitro cultivation system to produce Pv asexual and sexual erythrocytic stage parasites.
The present study used expressed sequence tags (ESTs) and EST tagged SNP patterns to examine the transcript structure variations resulting from allelic gene structure variations in the major human malaria vector, Anopheles gambiae.
Furthermore, the determinants of resistance in the other major human malaria parasite, P. vivax, are not known.
Finally, aiming at investigating whether the branches leading to the two major human malaria vectors, An. gambiae and An.
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A. gambiae mosquitoes are the major vectors of human malaria in sub-Saharan Africa.
The mosquito Anopheles gambiae is the major vector of human malaria throughout sub-Saharan Africa.
The mosquito Anopheles gambiae is a major vector of human malaria.
A. gambiae is a major vector of human malaria parasites in Africa, whose innate immune system protects the mosquito from infection by incompatible malaria parasites [ 28].
Anophelinae are recognized as major vectors of human malaria, while culicine species are the principal etiological agents of mosquito-borne viruses.
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main human malaria
severe human malaria
major human cancer
major African malaria
major human trial
major human development
major human toxicant
major human fungal
major human respiratory
major human malnutrition
major human ARDs
major local malaria
major human developmental
major human cytosolic
major asymptomatic malaria
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