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Minor RNA splicing defects can cause a major human developmental disorder.
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Retinoic acid induced 1 (RAis) is a protein of uncertain mechanism of action which nevertheless has been the focus of attention because it is a major contributing factor in several human developmental disorders including Smith Magenis and Potocki Lupski syndromes.
Chlamydia trachomatis is a major human pathogen with a unique obligate intracellular developmental cycle that takes place inside a modified cytoplasmic structure known as an inclusion.
Assessing risk for human developmental toxicity is a major obstacle in drug development, as it relies on data from animal experiments, with associated concordance problems.
Each of these secondary agents has been well-studied for developmental neurotoxicity in vivo and in vitro, and they all represent major human exposure hazards.
Processes for coordinating urban and rural development and the integration of urban-rural areas in China has been driven by four major forces: the economic development and urbanization level, bottom-up rural development, national government policy, and local human developmental state practices.
Finally, we discuss their impact on understanding human developmental cognition.
Similarly, excellent examples from human developmental disorders are overlooked.
This technology, although immeasurable on the opportunities for human developmental advancement, will, paradoxically further erode the notion of what it is to be human itself.
Gerton studies cohesinopathies, a group of rare human developmental disorders.
More than a third are suspected of affecting the human developmental and nervous systems.
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