Laffin and Petrash examined expression of AKR1B1 and AKR1B10 across all major human cancer types using database searching [48,49].
Among these genes, a significantly higher alteration profile for Ribophorin II (RPN2) and High- mobility group protein B1 (HMGB1) was observed in CRC tumors, compared to other eight major human solid cancer types, currently available in the TCGA database.
Major human hepatocyte protein classes are represented in the Tupaia hepatocytes proteome database generated in this study.
Malaria is the major human parasitic disease.
Major human rights challenges persist, however.
A major goal was to improve text mining systems for computer-assisted biocuration to support a human database curator rather than serving as a replacement.
Prieto and De Las Rivas [41] have shown a limited intersection and overlap between the six major PPI databases for human proteins (BioGRID, BIND, MINT, HPRD, IntAct, DIP) [42] [47].
In the following, we will introduce the new method BioSim for similarity searches based on diverse annotation sources of gene and protein function and extend the existing methods cosine similarity, kappa coefficient, simGIC and TO to utilize annotations not only from GO, but also from 22 major biological databases for human genes and proteins.
Hence, we used all the available PPI datasets for humans from five major databases as the basis for our studies.
Since PPI data that are specific to a cancer type do not exist in the public domain, we used all the available PPI datasets for humans from five major databases as the basis for our studies.
