Sentence examples for major human CYPs from inspiring English sources

Based on the observed turnovers, PiB is a substrate for all five of the major human CYPs, with rhCYP1A2 dominating.

The metabolism of PiB appears to be polyzymic, with at least two of the major human CYPs (1A2 and 3A4), contributing to metabolism, together with UDP-glucuronosyltransferase (UGT) involvement.

The advantages and limitations of applying cocktails for the in vitro activity assessment of major human CYPs, namely, CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1 and subfamily CYP3A, are discussed.

Since there is no data available on the relevance of the concentrations used for human exposure, in this mechanistic study, we conduct a systematic investigation of the impacts of AuNPs with different particle sizes and concentrations on five major human CYPs under normal in vitro microsomal incubations.

The extract tested in the study reported here, EGb 761®, was also tested for its ability to inhibit major human CYPs.

A screen of 15 major human CYP isoforms for metabolic ability with respect to carbofuran metabolism demonstrated that CYP3A4 is the major isoform responsible for carbofuran oxidation in humans.

Telatinib exhibited neither an inhibitory nor an inductive potential on major human CYP isoforms at therapeutically relevant concentrations.

We provide evidence that EGb 761® has no clinically relevant inhibitory or inducing effects toward the major human CYP enzymes when administered at chronic therapeutic doses in vivo.

Validated probe substrates to measure the functional activities of major human CYP isoforms, as well as some phase 2 conjugation pathways, in primary hepatocytes with corresponding recommendations for relevant concentrations, specific activity levels and analytical methods can be found in a number of related publications (Li et al., 1999; Zhang et al., 2009; Huang et al., 2007; Smith et al., 2012).

To meet this need, a rapid liquid chromatography tandem mass spectrometry (LC/MS/MS) method has been validated and employed for routine screening of new chemical entities for inhibition of six major human cytochrome P450 (CYP) isoforms using cDNA-expressed CYPs.

The human genome encodes 16 unique CYPs, categorized into 7 major groups, namely human CYP A (hCYP-A), hCYP-B, hCYP-C, hCYP-D, hCYP-E, hCYP-40 and hCYP-NK [ 6].