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The results confirm a major heterogeneity in the rationales and goals of R&D cooperation.
There was major heterogeneity of management processes related to MV within and across centers (mean IQV per center 0.51, SD 0.09).
Most previous prognostic studies in Parkinson's disease have used unrepresentative cohorts with selection biases resulting in major heterogeneity in estimates of mortality.
Beyond the imperfect animal models of critical illnesses, the failure of therapeutic clinical trials may be intrinsic to their design as they were aimed to treat a syndrome rather than a disease and thereby did not take into account the major heterogeneity of critically ill patients [22].
However, the Breslow-Day test confirmed that there was no major heterogeneity in the odds ratios, although the allele frequency differences were significant between several populations when controls from different populations were compared in a pair-wise manner with a standard association tests (Table S2).
Finally, major heterogeneity was present among included studies, limiting the validity of the meta-analysis.
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The mechanical component, the Lattice Discrete Particle Model (LDPM), permits the simulation of the failure behavior of concrete at the length scale of major heterogeneities.
Many cortical areas show major internal heterogeneity in their connectivity patterns that exceeds the variability reported here for repeat injections that were localized to a particular areal subregion.
Receptor level variation is a major source of heterogeneity between cells, though we acknowledge that other sources of heterogeneity could contribute (subsection "Cooperative IKK activation underlies dose-dependent response delay").
Addressing the major causes of heterogeneity remains therefore a major issue.
Tree fall gaps caused by natural disturbances are a major source of heterogeneity in intact forests.
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CEO of Professional Science Editing for Scientists @ prosciediting.com