These worms recapitulate all the major hallmarks of mtDNA disease in humans, including increased mtDNA instability, loss of respiration, reduced neuromuscular function, and a shortened lifespan.
Postmenopausal women are more susceptible to weight gain, fat redistribution and dyslipidemia, all major hallmarks of metabolic syndrome associated with increased NAFLD risk.
Accumulation of extracellular amyloid-β (Aβ) plaques, intracellular tangles in the brain, and formation of reactive oxygen species (ROS) are the major hallmarks of the disease.
The SNpc is the primary brain structure affected in Parkinson's disease, where loss of dopaminergic neurons is one of the major hallmarks of the disorder.
Amyloid-β protein (Aβ) accumulation is one of the major hallmarks of Alzheimer's disease (AD) and plays a crucial role in its pathogenesis.
Major hallmarks of psoriasis were confirmed by the evaluation of specific epidermal differentiation and proliferation markers as well as the mesenchymal milieu, including angiogenesis and infiltrate.
This integrative study reveals the immune landscape in human colorectal cancer and the major hallmarks of the microenvironment associated with tumor progression and recurrence.
One of the major hallmarks of adapted hPSCs is an improved ability to create stem cell colonies following replating as single cells in cloning efficiency assays (Enver et al., 2005; Harrison et al., 2007).
In an AD patient's brain, senile plaques and neurofibrillary tangles, the abnormal aggregates of amyloid β (Aβ) peptide and tau protein, are observed as the two major hallmarks of this disease.
Cost-consciousness and utility are major hallmarks of private entrepreneurship and WHP had to work within those parameters to make its services attractive to the potential entrepreneurs whom we hoped to enroll in our programs.
But support for the failed Cuba policy of the past - and hawkish opposition to the agreement that prevents Iran from getting nuclear weapons - are the major hallmarks of Rubio's shallow foreign policy experience.
