In contrast, folM deletion strains have no major growth defects, and trimethoprim does not inhibit FolM [58].
Here, we observed major growth defects in P. tricornutum cells overexpressing CDKA2.
Since major growth defects have been detected for mutants in different genes of this locus, Rigottier et al. [ 46] have proposed that these genes are important for the fitness of the bacterium rather than bona fide virulence factors.
We show here that expressing AOX rescues major impairments associated with COX deficiency especially the growth defect observed under selective conditions.
We have isolated and characterized mutations that overcome the growth defect of Bacillus subtilis ccpA mutants lacking the major regulator of catabolite repression, in particular their glutamate auxotrophy.
We also observed a major contribution of AGL080C to total PRPP synthetase activity, which was confirmed by an evident growth defect of the Δ agl080c strain.
We also observed a growth defect only in the double mutant in both L. donovani and L. major, which have higher multiplication rate at late logarithmic phase and start declining sooner than WT overexpression cells.
This evidence, the scientists wrote, indicated that the individuals were not modern humans "with an undiagnosed pathology or growth defect".
"Store pickup is our major growth driver.
