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A major genomic difference between the HERB-1 and US-1 lineages is the shift in ploidy, from diploid to triploid and even tetraploid.
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In attempting to explain virulence differences between strains of poxviruses, it may therefore be important to consider not only major genomic differences such as gene complement, but also diversifying selection in well conserved genes.
Apart from phenotype, most characteristics such as metabolism or physiology are shared between minipig and the Duroc pig and therefore we expect no major genomic differences caused by breeding or environmental adaptation as seen for the olfactory or hypoxia genes in the Tibetan wild boar [ 12].
a. paratuberculosis) can be divided into two major strains, sheep (S) and cattle (C), based on cultural requirements, host specificity, degree of clumping of cells in suspension and minor genomic differences including copy number of insertion elements and point mutations.
This limitation in identifying genetic relationships exists because a majority of genomic differences between pairs of individuals is contributed by frequent SNPs that form several (usually from two to five) major haplotypes in each loci (International HapMap Consortium 2003).
In contrast, major genome rearrangements mark significant genomic differences between the ancestral and the classical lineage (Fig. 3).
When examined at the genomic subgroup level, there was no difference in PLK1 mRNA expression among the four major genomic subgroups.
Our experiments were in agreement with previous studies that described few major genomic insertion or deletion events between the two strains, other than the RvD2 region of difference.
Richard Copley then presents a general EvoDevo perspective of major genomic changes having developmental consequences for the phenotype.
It identified a major genomic region, rpv1.
Two major genomic hotspots are on chromosomes 7 (7p11) and 12 (12q12-12).
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