Sentence examples for major genetic effects from inspiring English sources

The authors observed no major genetic effects of the analysed variants on depressiveness.

In one example, adaptive differentiation of native insects flushing on invasive plants arose from rapid epistatic divergence of novel, major genetic effects (Carroll et al. 2003).

It is well established that LD based association analysis is effective only for the genes underlying Mendelian traits or the genes with major genetic effects on polygenic traits [ 23, 33].

24 Even with the warfarin story, although major genetic effects have been identified, inclusion of these into models with clinical variables remains only moderately predictive of warfarin dose required or time to stabilise international normalised ratio.

22 In that case the genes were originally targeted as candidates because they were known to lie on the warfarin metabolic pathway, and it may be argued that major genetic effects on the anti-TNF response might be expected to arise from variation within genes implicated in the TNF pathway.

This could be interpreted to mean that in these mutation negative families individual non-genetic risk factors such as parity and menarche still contribute to risk in the context of a strong family history but rather more weakly, even in aggregate, than as yet undetected major genetic effects.

Multiple variants at the aldehyde dehydrogenase (ALDH) and alcohol dehydrogenase (ADH) loci have also been well documented as genes of major genetic effect especially in East-Asian populations [12], [13], [14], [15].

Although this analysis indicated that the major genetic effect on chromosome 17 maps outside the H2 region it is still possible that the H2 locus could contribute to the observed phenotype.

Genetic mapping of cell cycle duration revealed a four-locus genetic model, including a major genetic effect on chromosome 12, which accounts for 75% of the inherited phenotype variation.

As the major genetic effect of the FHB resistance genes is additive, it should be possible to accumulate different genes to enhance FHB resistance in wheat (Bai et al. 2000).

However, the results of the quantitative trait GWAS demonstrate that the sample size used was sufficient to detect a major genetic effect such as that manifested at the MSTN locus.